在Program.cs入口處新增方法：

 #region Mutex
        private static Mutex mutex = null;
        /// <summary>
        /// 重複啟動檢測
        /// </summary>
        /// <remarks>
        /// tips:此邏輯不能放在Main方法中
        /// Mutex會被銷燬，需專門封裝判斷方法
        /// </remarks>
        private static void GlobalMutex()
        {
            // 是否第一次建立mutex
            bool newMutexCreated = false;
            string mutexName = "Global\\" + "GH.DistributeCar_K3";
            try
            {
                mutex = new Mutex(false, mutexName, out newMutexCreated);

                if (!newMutexCreated)
                {
                    MessageDxUtil.ShowTips("另一個視窗已在執行，不能重複執行。");
                    System.Threading.Thread.Sleep(1000);
                    Environment.Exit(1);//退出程式
                }
            }
            catch (Exception ex)
            {
                Console.Write(ex.Message);
                System.Threading.Thread.Sleep(1000);
                Environment.Exit(1);
            }
        }
        #endregion

  #region ThreadExpection
        /// <summary>
        /// UI執行緒全域性異常處理
        /// </summary>
        /// <param name="sender"></param>
        /// <param name="e"></param>
        static void Application_ThreadException(object sender, ThreadExceptionEventArgs e)
        {
            log4NetUtil.Error("Application_ThreadException", e.Exception);
            string message = $"{e.Exception.Message}\r\n操作發生錯誤，您需要退出系統麼？";
            if (DialogResult.Yes == MessageDxUtil.ShowYesNoAndError(message))
            {
                Environment.Exit(1);
            }
        }
        #endregion

 　　　　#region UnhandledException
        /// <summary>
        /// 非UI執行緒全域性異常處理
        /// </summary>
        /// <param name="sender"></param>
        /// <param name="e"></param>
        static void CurrentDomain_UnhandledException(object sender, UnhandledExceptionEventArgs e)
        {
            Exception ex 
 
= e.ExceptionObject as Exception;
            log4NetUtil.Error(e.ToString(), ex);
            string message = $"{ex.Message}\r\n操作發生錯誤，您需要退出系統麼？";
            if (DialogResult.Yes == MessageDxUtil.ShowYesNoAndError(message))
            {
                Application.Exit();
            }
        }
        #endregion

Main呼叫示例:

  　　　　/// <summary>
        /// The main entry point for the application.
        /// </summary>
        [STAThread]
        static void Main()
        {
            GlobalMutex();

            Application.EnableVisualStyles();
            Application.SetCompatibleTextRenderingDefault(false);
            // 全域性異常捕獲
            Application.ThreadException += Application_ThreadException;
            AppDomain.CurrentDomain.UnhandledException += CurrentDomain_UnhandledException;

            BonusSkins.Register();
            SkinManager.EnableFormSkins();
            UserLookAndFeel.Default.SetSkinStyle("DevExpress Style");
            Application.Run(new FrmMain());
        }