// Instantiate the dialog box
            var dlg = new Microsoft.Win32.OpenFileDialog
            {
                FileName = "",
                Filter = "All Files|*.*|PNG Files|*.png|JPG Files|*.jpg|TIF Files|*.tif"
            };
            var result = dlg.ShowDialog();
            
 
// Process open file dialog box results
            if (result == true)
            {
                // Open a Stream and decode a TIFF image.
                Stream imageStreamSource = new FileStream(dlg.FileName, FileMode.Open, FileAccess.Read, FileShare.Read);
                var decoder = new TiffBitmapDecoder(imageStreamSource, BitmapCreateOptions.PreservePixelFormat, BitmapCacheOption.Default);
                BitmapSource bitmapSource 
 
= decoder.Frames[0];
                Int32 PixelHeight = bitmapSource.PixelHeight; // 影象高度
                Int32 PixelWidth = bitmapSource.PixelWidth;   // 影象寬度
                Int32 Stride = (PixelWidth * bitmapSource.Format.BitsPerPixel + 7) / 8;  // 跨距寬度
                if(bitmapSource.Format.BitsPerPixel ==8
 
)
                {
                    Byte[] gray8 = new Byte[PixelHeight * PixelWidth];//8bit 位深
                    bitmapSource.CopyPixels(gray8, Stride, 0);
                }
                else if (bitmapSource.Format.BitsPerPixel == 16)
                {
                    ushort[] gray16 = new ushort[PixelHeight * PixelWidth];//16bit 位深
                    bitmapSource.CopyPixels(gray16, Stride, 0);
                }
            }

效果如下：

            unsafe
            {
                int lenth = width * height;//相機buff照片的寬度和高度
                UInt16* bufi = (UInt16*)buf.ToPointer();//從相機buff中讀取16bit灰度資料
                UInt16[] data = new UInt16[lenth];
                byte[] bufBytes = new byte[lenth*2];

                for (int i = 0; i < lenth; i++)
                {
                    data[i] = bufi[i];
                }
                IntPtr intptr = Marshal.UnsafeAddrOfPinnedArrayElement(data, 0);
                Marshal.Copy(intptr,bufBytes,0,lenth*2);//將16bit資料轉化成兩個8bit資料

                BitmapPalette myPalette = BitmapPalettes.Gray16;
                int rawStride = (width * 16 + 7) / 8;//16bit 位深

                BitmapSource image = BitmapSource.Create(width, height, 96, 96, PixelFormats.Gray16, myPalette, bufBytes, rawStride);

                FileStream f = new FileStream(name, FileMode.Create);
                TiffBitmapEncoder encoder = new TiffBitmapEncoder();//tif編碼格式

                encoder.Compression = TiffCompressOption.Zip;
                encoder.Frames.Add(BitmapFrame.Create(image));
                encoder.Save(f);
                f.Close();
            }

參考連結https://docs.microsoft.com/zh-cn/dotnet/desktop/wpf/graphics-multimedia/how-to-encode-and-decode-a-tiff-image?view=netframeworkdesktop-4.8