sight risk in childhood: But fertility treatment may protect against development of myopia, twin study suggests
But fertility treatment may be protective, the findings suggest.
Myopia is defined as a refractive error, meaning that the eye can't focus light properly. The result is that close objects look clear, but distant ones appear blurred.
It can be corrected with prescription glasses, laser surgery, or contact lenses, but the condition is linked to a heightened risk of visual impairment and sight loss in later life.
And it is becoming increasingly common: 4.758 billion people worldwide are likely to be affected by 2050, up from 1.950 billion in 2010.
Genes are thought to have a role, but they don't fully explain the rising prevalence. And given the rapid development of the eyes in early life, the researchers wanted to explore potential contributory environmental factors across the life course.
They studied 1991 twins whose age was 16.7 years, on average. The twins were all born between 1994 and 1996 in the UK, and taking part in the long term Twins Early Development Study (TEDS).
Opticians provided information from their eye tests about myopia, and the researchers analysed demographic, social, economic, educational and behavioural factors in the twin pairs from when these children were 2,3,4,7,8,10,12,14, and 16 years old, to capture critical stages of child and eye development.
Parents and teachers filled in comprehensive questionnaires and the twins did web based assessments to provide a wide range of background and potentially relevant information on factors that might have influenced early life development.
The average age at which children with myopia started wearing glasses to correct the condition was 11. Around one in 20 (5.4%) had a 'lazy eye' (amblyopia) and a similar proportion (nearly 4.5%) had a squint. Overall, one in four (26%) of the twins was myopic.
The factors most strongly associated with the development of myopia across the various time points were the mother's educational attainment (university or postgraduate level), hours spent playing computer games, and being born during the summer.
Hours spent playing computer games may not just be linked to close working, but also to less time outdoors-a factor that has previously been linked to heightened myopia risk.
Educational level has also been linked to myopia, and as child in the UK born in the summer months will start school at a younger age than those born during the winter months, the researchers suggest that this earlier close work may speed up eye growth which is responsible for short-sightedness.
Higher levels of household income and measures of intelligence, particularly verbal dexterity scores, were associated with heightened risk, but to a lesser extent.
Fertility treatment seemed to afford protection against myopia and was associated with a 25-30 per cent lower risk. The researchers speculate that children born as a result of fertility treatment are often born smaller and slightly more premature, and may have some level of developmental delay, which might account for shorter eye length and less myopia.
This is an observational study, and as such, can't establish cause, say the researchers, highlighting that future research may be able to look at the interplay between genetic susceptibility and environmental influences.
In a linked editorial, Drs Mohamed Dirani, Jonathan Crowston, and Tien Wong, of, respectively, the Singapore National Eye Centre, Centre for Eye Research, Melbourne, Australia, and the Department of Surgery, University of Melbourne, point out that environmental factors are now thought to have a greater role than genetic ones.
They add that the study involved data gathered before the explosion in digital media.
"The rapid adoption of smart devices in children adds a new dimension to how we define and quantify near-work activity," they write...The role of smart devices, quantified as device screen time (DST) must also be investigated."
And children start using these devices at an increasingly younger age. "The increased DST resulting from gaming, social media, and digital entertainment has led to a rise in sedentary behaviour, poor diet and a lack of outdoor activity," they suggest.
"The use and misuse of smart devices, particularly in our paediatric populations, must be closely monitored to address the emerging phenomenon of digital myopia," they conclude.