1、專案的build.gradle中新增

classpath ('com.tencent.tinker:tinker-patch-gradle-plugin:1.9.1')

2、APP的build.gradle：
(1)、新增依賴
（2）、添加簽名資訊配置
（3）、開啟混淆
（4）、新增Tinker的相關配置

apply plugin: 'com.android.application'
android {
    compileSdkVersion 24
    buildToolsVersion "23.0.3"
    //簽名信息配置
    signingConfigs {
        release {
            try
 
 {
                storeFile file("./keystore/tinker.jks")
                keyAlias "tinker"
                storePassword "123456"
                keyPassword "123456"
            } catch (ex){
                throw new InvalidUserDataException(ex.toString())
            }
        }
        debug {
            storeFile file("./keystore/debug.keystore"
 
)
        }
    }

    defaultConfig {
        applicationId "com.lee.tinkerdemo"
        minSdkVersion 15
        targetSdkVersion 24
        versionCode 1
        versionName "1.0"
        testInstrumentationRunner "android.support.test.runner.AndroidJUnitRunner"

        //Tinker相關配置start======================================
 

        multiDexEnabled true
        buildConfigField "String", "MESSAGE", "\"I am the base apk\""
        buildConfigField "String", "TINKER_ID", "\"${getTinkerIdValue()}\""
        buildConfigField "String", "PLATFORM",  "\"all\""
        //Tinker相關配置end======================================

    }
    buildTypes {
        release {
            minifyEnabled true
            signingConfig signingConfigs.release
            proguardFiles getDefaultProguardFile('proguard-android.txt'), 'proguard-rules.pro'
        }
        debug {
            debuggable true
            minifyEnabled true
            signingConfig signingConfigs.release
            proguardFiles getDefaultProguardFile('proguard-android.txt'), 'proguard-rules.pro'
        }
    }
}

dependencies {
    compile fileTree(dir: 'libs', include: ['*.jar'])
    androidTestCompile('com.android.support.test.espresso:espresso-core:2.2.2', {
        exclude group: 'com.android.support', module: 'support-annotations'
    })
    compile 'com.android.support:appcompat-v7:24.2.1'
    testCompile 'junit:junit:4.12'
    //可選，用於生成application類 
    provided('com.tencent.tinker:tinker-android-anno:1.9.1'){ changing = true }
    //tinker的核心庫
    compile('com.tencent.tinker:tinker-android-lib:1.9.1'){ changing = true }
    // 多dex 打包的類庫
    compile "com.android.support:multidex:1.0.1"
}


//============Tinker相關配置start=================
def bakPath = file("${buildDir}/bakApk/")

ext {
    //是否開啟tinker的功能
    tinkerEnabled = true

    //old apk地址
    tinkerOldApkPath = "${bakPath}/app-release-1214-15-40-00.apk"
    //old apk 混淆檔案地址
    tinkerApplyMappingPath = "${bakPath}/app-release-1214-15-40-00-mapping.txt"
    //old apk R 檔案地址
    tinkerApplyResourcePath = "${bakPath}/app-release-1214-15-40-00-R.txt"

    //多渠道打包相關
    tinkerBuildFlavorDirectory = "${bakPath}/app-release-1214-15-40-00"
}


def getOldApkPath() {
    return ext.tinkerOldApkPath
}

def getApplyMappingPath() {
    return ext.tinkerApplyMappingPath
}

def getApplyResourceMappingPath() {
    return ext.tinkerApplyResourcePath
}

def getTinkerIdValue() {
    return 1.0
}

def buildWithTinker() {
    return ext.tinkerEnabled
}

def getTinkerBuildFlavorDirectory() {
    return ext.tinkerBuildFlavorDirectory
}

if (buildWithTinker()) {
    apply plugin: 'com.tencent.tinker.patch'

    tinkerPatch {
        /**
         * necessary，default 'null'
         * the old apk path, use to diff with the new apk to build
         * add apk from the build/bakApk
         */
        oldApk = getOldApkPath()
        /**
         * optional，default 'false'
         * there are some cases we may get some warnings
         * if ignoreWarning is true, we would just assert the patch process
         * case 1: minSdkVersion is below 14, but you are using dexMode with raw.
         *         it must be crash when load.
         * case 2: newly added Android Component in AndroidManifest.xml,
         *         it must be crash when load.
         * case 3: loader classes in dex.loader{} are not keep in the main dex,
         *         it must be let tinker not work.
         * case 4: loader classes in dex.loader{} changes,
         *         loader classes is ues to load patch dex. it is useless to change them.
         *         it won't crash, but these changes can't effect. you may ignore it
         * case 5: resources.arsc has changed, but we don't use applyResourceMapping to build
         */
        ignoreWarning = true

        /**
         * optional，default 'true'
         * whether sign the patch file
         * if not, you must do yourself. otherwise it can't check success during the patch loading
         * we will use the sign config with your build type
         */
        useSign = true

        /**
         * optional，default 'true'
         * whether use tinker to build
         */
        tinkerEnable = buildWithTinker()

        /**
         * Warning, applyMapping will affect the normal android build!
         */
        buildConfig {
            /**
             * optional，default 'null'
             * if we use tinkerPatch to build the patch apk, you'd better to apply the old
             * apk mapping file if minifyEnabled is enable!
             * Warning:
             * you must be careful that it will affect the normal assemble build!
             */
            applyMapping = getApplyMappingPath()
            /**
             * optional，default 'null'
             * It is nice to keep the resource id from R.txt file to reduce java changes
             */
            applyResourceMapping = getApplyResourceMappingPath()

            /**
             * necessary，default 'null'
             * because we don't want to check the base apk with md5 in the runtime(it is slow)
             * tinkerId is use to identify the unique base apk when the patch is tried to apply.
             * we can use git rev, svn rev or simply versionCode.
             * we will gen the tinkerId in your manifest automatic
             */
            tinkerId = getTinkerIdValue()

            /**
             * if keepDexApply is true, class in which dex refer to the old apk.
             * open this can reduce the dex diff file size.
             */
            keepDexApply = false

            //是否開啟加固
            isProtectedApp = false
        }

        dex {
            /**
             * optional，default 'jar'
             * only can be 'raw' or 'jar'. for raw, we would keep its original format
             * for jar, we would repack dexes with zip format.
             * if you want to support below 14, you must use jar
             * or you want to save rom or check quicker, you can use raw mode also
             */
            dexMode = "jar"

            /**
             * necessary，default '[]'
             * what dexes in apk are expected to deal with tinkerPatch
             * it support * or ? pattern.
             */
            pattern = ["classes*.dex",
                       "assets/secondary-dex-?.jar"]
            /**
             * necessary，default '[]'
             * Warning, it is very very important, loader classes can't change with patch.
             * thus, they will be removed from patch dexes.
             * you must put the following class into main dex.
             * Simply, you should add your own application {@code tinker.sample.android.SampleApplication}
             * own tinkerLoader, and the classes you use in them
             *
             */
//            loader = [
//                    //use sample, let BaseBuildInfo unchangeable with tinker
//                    "tinker.sample.android.app.BaseBuildInfo"
//            ]
            loader = ["com.tencent.tinker.loader.*", "com.lee.tinkerdemo.SimpleTinkerInApplication"]
        }

        lib {
            /**
             * optional，default '[]'
             * what library in apk are expected to deal with tinkerPatch
             * it support * or ? pattern.
             * for library in assets, we would just recover them in the patch directory
             * you can get them in TinkerLoadResult with Tinker
             */
            pattern = ["lib/*/*.so"]
        }

        res {
            /**
             * optional，default '[]'
             * what resource in apk are expected to deal with tinkerPatch
             * it support * or ? pattern.
             * you must include all your resources in apk here,
             * otherwise, they won't repack in the new apk resources.
             */
            pattern = ["res/*", "assets/*", "resources.arsc", "AndroidManifest.xml"]

            /**
             * optional，default '[]'
             * the resource file exclude patterns, ignore add, delete or modify resource change
             * it support * or ? pattern.
             * Warning, we can only use for files no relative with resources.arsc
             */
            ignoreChange = ["assets/sample_meta.txt"]

            /**
             * default 100kb
             * for modify resource, if it is larger than 'largeModSize'
             * we would like to use bsdiff algorithm to reduce patch file size
             */
            largeModSize = 100
        }

        packageConfig {
            /**
             * optional，default 'TINKER_ID, TINKER_ID_VALUE' 'NEW_TINKER_ID, NEW_TINKER_ID_VALUE'
             * package meta file gen. path is assets/package_meta.txt in patch file
             * you can use securityCheck.getPackageProperties() in your ownPackageCheck method
             * or TinkerLoadResult.getPackageConfigByName
             * we will get the TINKER_ID from the old apk manifest for you automatic,
             * other config files (such as patchMessage below)is not necessary
             */
            configField("patchMessage", "tinker is sample to use")
            /**
             * just a sample case, you can use such as sdkVersion, brand, channel...
             * you can parse it in the SamplePatchListener.
             * Then you can use patch conditional!
             */
            configField("platform", "all")
            /**
             * patch version via packageConfig
             */
            configField("patchVersion", "1.0")
        }
        //or you can add config filed outside, or get meta value from old apk
        //project.tinkerPatch.packageConfig.configField("test1", project.tinkerPatch.packageConfig.getMetaDataFromOldApk("Test"))
        //project.tinkerPatch.packageConfig.configField("test2", "sample")

        /**
         * if you don't use zipArtifact or path, we just use 7za to try
         */
        sevenZip {
            /**
             * optional，default '7za'
             * the 7zip artifact path, it will use the right 7za with your platform
             */
            zipArtifact = "com.tencent.mm:SevenZip:1.1.10"
            /**
             * optional，default '7za'
             * you can specify the 7za path yourself, it will overwrite the zipArtifact value
             */
//        path = "/usr/local/bin/7za"
        }
    }

    List<String> flavors = new ArrayList<>();
    project.android.productFlavors.each {flavor ->
        flavors.add(flavor.name)
    }
    boolean hasFlavors = flavors.size() > 0
    def date = new Date().format("MMdd-HH-mm-ss")

    /**
     * bak apk and mapping
     */
    android.applicationVariants.all { variant ->
        /**
         * task type, you want to bak
         */
        def taskName = variant.name

        tasks.all {
            if ("assemble${taskName.capitalize()}".equalsIgnoreCase(it.name)) {

                it.doLast {
                    copy {
                        def fileNamePrefix = "${project.name}-${variant.baseName}"
                        def newFileNamePrefix = hasFlavors ? "${fileNamePrefix}" : "${fileNamePrefix}-${date}"

                        def destPath = hasFlavors ? file("${bakPath}/${project.name}-${date}/${variant.flavorName}") : bakPath
                        from variant.outputs.outputFile
                        into destPath
                        rename { String fileName ->
                            fileName.replace("${fileNamePrefix}.apk", "${newFileNamePrefix}.apk")
                        }

                        from "${buildDir}/outputs/mapping/${variant.dirName}/mapping.txt"
                        into destPath
                        rename { String fileName ->
                            fileName.replace("mapping.txt", "${newFileNamePrefix}-mapping.txt")
                        }

                        from "${buildDir}/intermediates/symbols/${variant.dirName}/R.txt"
                        into destPath
                        rename { String fileName ->
                            fileName.replace("R.txt", "${newFileNamePrefix}-R.txt")
                        }
                    }
                }
            }
        }
    }
    project.afterEvaluate {
        //sample use for build all flavor for one time
        if (hasFlavors) {
            task(tinkerPatchAllFlavorRelease) {
                group = 'tinker'
                def originOldPath = getTinkerBuildFlavorDirectory()
                for (String flavor : flavors) {
                    def tinkerTask = tasks.getByName("tinkerPatch${flavor.capitalize()}Release")
                    dependsOn tinkerTask
                    def preAssembleTask = tasks.getByName("process${flavor.capitalize()}ReleaseManifest")
                    preAssembleTask.doFirst {
                        String flavorName = preAssembleTask.name.substring(7, 8).toLowerCase() + preAssembleTask.name.substring(8, preAssembleTask.name.length() - 15)
                        project.tinkerPatch.oldApk = "${originOldPath}/${flavorName}/${project.name}-${flavorName}-release.apk"
                        project.tinkerPatch.buildConfig.applyMapping = "${originOldPath}/${flavorName}/${project.name}-${flavorName}-release-mapping.txt"
                        project.tinkerPatch.buildConfig.applyResourceMapping = "${originOldPath}/${flavorName}/${project.name}-${flavorName}-release-R.txt"
                    }
                }
            }

            task(tinkerPatchAllFlavorDebug) {
                group = 'tinker'
                def originOldPath = getTinkerBuildFlavorDirectory()
                for (String flavor : flavors) {
                    def tinkerTask = tasks.getByName("tinkerPatch${flavor.capitalize()}Debug")
                    dependsOn tinkerTask
                    def preAssembleTask = tasks.getByName("process${flavor.capitalize()}DebugManifest")
                    preAssembleTask.doFirst {
                        String flavorName = preAssembleTask.name.substring(7, 8).toLowerCase() + preAssembleTask.name.substring(8, preAssembleTask.name.length() - 13)
                        project.tinkerPatch.oldApk = "${originOldPath}/${flavorName}/${project.name}-${flavorName}-debug.apk"
                        project.tinkerPatch.buildConfig.applyMapping = "${originOldPath}/${flavorName}/${project.name}-${flavorName}-debug-mapping.txt"
                        project.tinkerPatch.buildConfig.applyResourceMapping = "${originOldPath}/${flavorName}/${project.name}-${flavorName}-debug-R.txt"
                    }
                }
            }
        }
    }
}
//==========Tinker相關配置start===============

在APP的build.gradle 中的

loader = ["com.tencent.tinker.loader.*", "新增在manifest中註冊的Application"]

例如：

loader = ["com.tencent.tinker.loader.*", "com.lee.tinkerdemo.SimpleTinkerInApplication"]

3、新建Application

@SuppressWarnings("unused")
@DefaultLifeCycle(application = "com.lee.tinkerdemo.SimpleTinkerInApplication",
        flags = ShareConstants.TINKER_ENABLE_ALL,
        loadVerifyFlag = false)
public class SimpleTinkerInApplicationLike extends DefaultApplicationLike {
    public SimpleTinkerInApplicationLike(Application application, int tinkerFlags,
                                         boolean tinkerLoadVerifyFlag, long applicationStartElapsedTime, 
                                         long applicationStartMillisTime, Intent tinkerResultIntent) {
        super(application, tinkerFlags, tinkerLoadVerifyFlag, applicationStartElapsedTime, 
                applicationStartMillisTime, tinkerResultIntent);
    }
    @TargetApi(Build.VERSION_CODES.ICE_CREAM_SANDWICH)
    @Override
    public void onBaseContextAttached(Context base) {
        super.onBaseContextAttached(base);
        // 其原理是分包架構，所以在載入初要載入其餘的分包
        MultiDex.install(base);
        TinkerInstaller.install(this);
    }
    public static SimpleTinkerInApplicationLike sApp;
    @Override
    public void onCreate() {
        super.onCreate();
        sApp = this;
    }
    @TargetApi(Build.VERSION_CODES.ICE_CREAM_SANDWICH)
    public void registerActivityLifecycleCallbacks(Application.ActivityLifecycleCallbacks callback) {
        // 生命週期，預設配置
        getApplication().registerActivityLifecycleCallbacks(callback);
    }
    public static SimpleTinkerInApplicationLike getApp(){
        return sApp;
    }
}

4、Mainactivity

public class MainActivity extends AppCompatActivity {
    @Override
    protected void onCreate(Bundle savedInstanceState) {
        super.onCreate(savedInstanceState);
        setContentView(R.layout.activity_main);
        // 載入補丁包
        TinkerInstaller.onReceiveUpgradePatch(getApplicationContext(),
                Environment.getExternalStorageDirectory().getAbsolutePath() + "/tinker/patch_signed_7zip.apk"); //補丁包路徑和名字可以自定義
        //清除補丁包
        //        Tinker.with(getApplicationContext()).cleanPatch();
    }
    /**
     * =====================Tinker 預設配置========================
     */
}

5、正常打包release，然後把release安裝到手機上
6、開啟app—>build—>bakApk，把裡面的apk、-mapping.txt、-R.txt的名稱複製到app/build.gradle中Tinker配置的相應位置去

6、修改MainActivity中介面，然後點選最右側一欄的gradle，開啟專案名稱選項—>Tasks—>tinker—–>tinkerPatchRelease

7、開啟app/outputs/tinkerPatch/release，複製patch_signed_7zip.apk到Mainactivity中指定的位置處，並且修改名稱和Mainactivity中的名稱一樣