★Integrated Database Retrieval Systems

★Entrez 
http://www.ncbi.nlm.nih.gov/Entrez/default.htm 

★Sequence Retrieval System (SRS) 
http://www.seqnet.dl.ac.uk/srs/srsc   

★The Institute for Genomic Research (TIGR), Human Gene Index (HGI) Sequence Search 
4-1-2-DDPDE/USA 
http://www.tigr.org/tdb/hgi/searching/hgi_seq_search.html 
Search for nucleotides and peptides. 

★TIGR HGI Reports 
3-1-2-DDcW/USA 

http://www.tigr.org/tdb/hgi/searching/hgi_info.html 
Retrieve sequences identified by EST ID, GenBank number etc. 

★TIGR HGI Gene Expression Data 
4-2-1-DDcW/USA 
http://www.tigr.org/tdb/hgi/searching/hgi_xpress_search.html 
Search for tissue specific transcripts e.g. "lung". cDNA libraries can also be searched. 


★TIGR HGI Name Search 
5-1-2-DDW/USA 

http://www.tigr.org/tdb/hgi/searching/hgi_name_search.html 
Search for a sequence by the name of a gene product e.g. insulin. 

★Genome Database (GDB) 
http://hgmp.mrc.ac.uk/gdb or http://gdbwww.gdb.org/default.htm 
Funding for this project has been withdrawn. This valuable database will remain online, but it should be noted that no new entries will be recorded after 31st July 1998. 


序列列線
★Analysis and Annotation Tool for Finding Genes in Genomic Sequences 
5-3-2-DcDPDFWE/USA 

http://genome.cs.mtu.edu/aat.html 
Identifies genes in a DNA sequence by comparing it to cDNA and protein sequence databases (including those at HGI, TIGR, dbEST, Swiss-Prot and nr). 

★Pairwise Sequence Alignment 
3-4-2-DcUPUFWE/USA 
http://genome.cs.mtu.edu/align/align.html 
Computes the global alignment between two sequences. Compare DNA with DNA, cDNA or protein. For DNA and cDNA, settings (gap open penalty, gap extension etc.) can be defined. 

★Multiple Sequence Alignemnt with MAP 
4-3-2-DcUPUFWE/USA 
http://genome.cs.mtu.edu/map/map.html 
Calculates the global alignment of DNA or protein sequences using an algorithm which computes the best overlapping alignment without penalising terminal gaps. Long internal gaps in short sequences are not penalised. 

★Network Protein Sequence Analysis 
5-4-1-PUW/France 
http://pbil.ibcp.fr/NPSA/npsa_clustalw.html 
ClustalW multiple sequence alignment. 

★ALIGN 
5-1-1-DUPUWE/France 
http://www2.igh.cnrs.fr/bin/align-guess.cgi or http://genome.eerie.fr/fasta/align-query.html 
Applies the BLOSUM50 matrix to deduce the optimal alignment between two sequences. 

★Multiple Sequence Alignment with Hierarchial Clustering 
5-5-3-PUW/France 
http://www.toulouse.inra.fr/multalin.html 
Sequence alignment with a colour output where differing or similar amino acids in the alignment can be highlighted. 

★Colour INteractive Editor for Multiple Alignments (CINEMA) 
http://www.biochem.ucl.ac.uk/bsm/dbbrowser/CINEMA2.1/default.htm 
A comprehensive and popular site. Allows the user to visualise and manipulate aligned protein sequences. 
Makes use of Java. I recommend you access this site from a fast workstation! 

★VSNS BioComputing Division Multiple Alignment Resource Page 
http://www.techfak.uni-bielefeld.de/bcd/Curric/MulAli/default.htm 
An excellent, comprehensive resource for multiple sequence alignment, software and tutorials. 


新序列傳送:

★EMBL 
http://www.ebi.ac.uk/subs/emblsubs.html 

★BankIt (GenBank) 
http://www.ncbi.nlm.nih.gov/default.htm